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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Cytokine. 2016 Aug 4;87:37–45. doi: 10.1016/j.cyto.2016.06.023

Figure 1. Ligand recognition and atypical signalling by the chemokine decoy and scavenger receptor ACKR2.

Figure 1

ACKR2 binds with high affinity inflammatory CC chemokines; it signals through β-arrestin and the small GTPase Rac1 activating cytoskeleton rearrangement in order to optimize the chemokine scavenging activity. It is not known if the interaction of ACKR2 with β-arrestin could have an inhibitory function on other signalling pathways.