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. 2016 May 11;22(6):497–510. doi: 10.1016/j.molmed.2016.04.007

Figure 2.

Figure 2

Role of PTX3 in Innate Immunity. The binding of PTX3 to select microorganisms, including bacteria, fungi, and viruses, leads to the activation of various antimicrobial effector mechanisms, such as phagocytosis and viral neutralization and inactivation (green arrows). However, it can also lead to potentially dangerous inflammatory reactions or even facilitate viral entry (red arrows). Abbreviations: UPEC, uropathogenic Escherichia coli; IAV, influenza A virus; CMV, cytomegalovirus; CHIKV, Chikungunya virus; RRV, Ross River virus.