Figure 4. Alteration of hepatic GJIC after APAP overdosing.
(A) Mice (n = 5) were injected with 300 mg/kg APAP or saline (SAL) followed by assessment of GJIC by diffusion of Lucifer Yellow (green color) at different time points (i.e. after 0, 1, 6 and 24 hours). The white scale bar represents 50 µm. (B) The dye transfer ratios were quantified and normalized against untreated animals. Data are expressed as means ± SEM with *p ≤ 0.05 compared to saline at indicated time points.