Table 3.

Functional deficits in antigen presentation in tumor cells of classical Hodgkin lymphoma, diffuse large B-cell lymphoma and primary central nervous system lymphoma patients.

Antigen presentation capability	cHL %	NLPHL %	DLBCL %	PCNSL %	Testis %
“Normal”	12.4	90.4	37.6	23.5	13.3
HLA class I dysfunction	17.6	4.8	19.7	17.7	0
HLA class II dysfunction	24.1	0	7.7	5.9	6.7
HLA class I and II dysfunction	45.9	4.8	35.0	52.9	80

Notes: Membraneous expression of HLA class I and class II with cytoplasmic HLA-DM. HLA class I dysfunction indicates loss of membraneous HLA class I staining with preserved membraneous HLA class II and cytoplasmic HLA-DM. HLA class II dysfunction refers to loss of HLA class II or loss of HLA-DM with preserved membraneous HLA class I. HLA class I and II dysfunction indicates loss of membraneous HLA class I combined with either loss of membraneous class II or loss of HLA-DM