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. 2017 Feb 21;6(4):e1293213. doi: 10.1080/2162402X.2017.1293213

Figure 4.

Figure 4.

ALOXs and GPR32 involvement in GC angiogenic response. (A) Tumor growth curves of AGS shCTR, shALOX5 (three clones) and shALOX15 (three clones) xenografts in immunodeficient mice. *p < .05 compared to shCTR xenografts. (B) Representative images and quantification (five fields/sample) of the proliferation index (Ki-67), vessel density (CD31), and apoptotic rate (Cleaved Caspase 3), assessed by immunohistochemistry, of shCTR, shALOX5, and shALOX15 cell xenografts harvested 28 d post-inoculation. *p < .05 compared to shCTR xenografts. (C) ALOX15 and ALOX5 mRNA expression levels of 295 patients affected by gastric adenocarcinoma stratified for disease-free and overall survival status. *p < .05 between the two groups. (D) Tumor growth curves of AGS shCTR and shGPR32 xenografts (average of three clones) cells in immunodeficient mice *p < .05 compared to shCTR xenografts. (E) Representative images of the vessel density (CD31), assessed by immunohistochemistry, of shCTR and shGPR32 AGS cell xenografts harvested 28 d post-inoculation.