. 2014 Mar 10;28(4):429–441. doi: 10.1210/me.2013-1414

Table 1.

A Collection of Mouse Models With Somatic Mutations Altering TH Signaling

Floxed Gene	Cre and Driving Promoter	Cell Types	Direct Effect	Reference
Dio2	CGA-Cre	Pituitary cells	High TSH level	90
Dio2	GFAP-Cre	Astrocytes	Normal TSH level. Increased fatty acid oxidation for energy expenditure.	90
Dio2	Fabp4-Cre	Adipocytes	Increased carbohydrate oxidation for energy expenditure	121
Dio2	MLC-Cre	Myocytes	No metabolic phenotype	121
NcoR	CGA-Cre	Pituitary cells	Low TSH level	29
Thra	CAG-Cre-ER^T	All cells after tamoxifen treatment	Reduced postnatal growth.	84
Thra	Nestin-Cre	Whole brain	Lethality	110
Thra	Cnp-Cre	Oligodendrocytes and neurons	OPCs proliferation in adult brain	115
Thra	PDGFRα-Cre-ER^T2	Several cell types after tamoxifen treatment	Delayed myelination	115
Thra	Ptf1a-Cre	GABAergic neurons including Purkinje cells	Altered neuronal differentiation.	110
Thra	L7-Cre	Purkinje cells after P8	Reduced synaptic density	110
Thra	Otx2-Cre-ER^T2	Granular cells	No effect	110
Thra	Glast-Cre-ER^T2	Astrocytes and Bergmann glia	Altered Bergmann glia	110
Thra	Thyr-Cre	Thyrocytes	Low T₄ level	92
Thra	Amh-Cre	Sertoli cells	Testis development	119
Thra	Math1-Cre-ER^T	Inner ear hair cells	Increased auditory response	102
Thrb	Prestin-Cre	Inner ear hair cells	Decreased auditory response	101
Thrb	Math1-Cre-ER^T	Inner ear hair cells	Decreased auditory response	102
Thrb	MHCα-Cre	Cardiomyocytes	No effect	120

GFAP, glial fibrillary acid protein; MHC, myosin heavy chain; PDGFR, platelet-derived growth factor receptor.