Effect of saffron on blood glucose level (mg/dl). Control (C), untreated diabetic rats (D), saffron extract (10 mg/kg/day)-treated diabetic (D + Sf1), saffron (20 mg/kg/day)-treated diabetic (D + Sf2) and saffron (40 mg/kg/day)-treated diabetic (D + S3) rats during 4 weeks of study (n = 9, for each group). Values are the mean ± SEM. Statistical significance for the difference between the data of the control group vs other groups: *p < 0.05; **p < 0.01, ***p < 0.001. Statistical significance for the difference between the data of untreated diabetic group vs treated groups: +p < 0.05; ++p < 0.01, +++p < 0.001.