Figure 6.

Hippocampus brain-derived neurotrophic factor depletion does not alter noradrenergic innervation in wild type mice.

(a) Representative images of AAV-GFP injected (left, control) and AAV-Cre injected (right, BDNF KO) HC from a WT (BDNF^f/f: 5XFAD^−/−) mouse, stained for DβH. (b) Quantitation of DβH staining shows no change in the HC due to BDNF depletion. (c) Quantitation of DβH staining in the CB of the same mice also shows no difference in DβH staining. Data show mean ± SEM, n = 4 matched pairs, 8 to 12 sections per region per animal. Results of student’s paired t tests are nonsignificant. (d) Comparison of DβH staining in HC of WT to 5XFAD mice, n = 3 per group, 8 to 12 sections per region per mouse.

*p < .05, Student’s paired t test.