Table 1.
Included studies: Methodology and participant characteristics
| Study | Design, location and time of study | Patient population | Sample size | Mean age (years) | Gender (% female) |
|---|---|---|---|---|---|
| Fiss et al., 201323 | Prospective cohort; Germany | Elderly patients in primary care with home-based assessment; subset had home-based medication reviews | Total, N = 342 Suspected dementia, n = 111 No signs of dementia, n = 231 |
80.9 82.7 with dementia 80 without dementia |
31.7 with dementia 69.3 without dementia |
| Koyama et al., 201324 | Longitudinal cohort; United States; enrolled 1986-1988; followed for 10 years; study of osteoporotic fractures; follow-up at 6 years and 10 years for medication reviews | Community-dwelling women 75 years of age and older | Total, N = 1484 | 78 | 100 |
| Lau et al., 201025 | Retrospective cohort; United States; September 2005–September 2007; National Alzheimer’s Coordinating Center, Uniform Data Set | Community-dwelling seniors 65 years of age and older | Total, N = 4518 (4087
analyzed) Dementia (+), n = 2665 (2467 analyzed) Dementia (–), n = 1853 (1620 analyzed) |
77 total sample 77.7 with dementia 76 without dementia |
59 |
| Lau et al., 201126 | Retrospective cohort, United States; September 2005–September 2009; National Alzheimer’s Coordinating Center, Uniform Data Set | Community-dwelling seniors 65 years or older with dementia | Dementia (+), N = 1994 | 77 | 49.2 |
| Montastruc et al., 201327 | Prospective cohort; France, enrolled 2000-2002; followed for 4 years | Community-dwelling patients with mild to moderate Alzheimer’s disease | 684 | 77.9 | 71.1 |
| Pugh et al., 201128 | Retrospective cross-sectional database; United States; 2004-2006; Healthcare Effectiveness Data and Information Data Set; outpatient and pharmacy data | Community-dwelling veterans | Total, N = 131,808 with
dementia With drug-disease interaction, n = 26,650 Without drug-disease interaction, n = 105,158 |
78.5 with drug-disease interaction 79.5 without drug-disease interaction |
2.9 with drug interaction 2.1 without drug interaction |
| Thorpe et al., 201229 | Secondary analysis of prospective data study; United States; 1996-2001; Resource for Enhancing Alzheimer’s Caregiver Health study | Family caregivers and dementia patients | Total, N = 566 Dementia patients, n = 187 Caregivers, n = 379 |
79.5 with dementia 74.2 caregivers |
Not reported |