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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: Nature. 2010 Nov 10;468(7327):1119–1123. doi: 10.1038/nature09589

Figure 4. I-BET suppresses inflammation in vivo.

Figure 4

a, Kaplan-Meier survival curves of: LPS-treated C57BL/6 mice (5 mg/kg, i.p., n=12 per group) that were injected i.v. with a solvent control (black squares) or 30 mg/kg of I-BET 1 hour before (blue triangles) or 1.5 hours after (blue circles) LPS administration (left panel); mice injected i.v. with heat-killed Salmonella typhimurium, strain IR71 (5×109/kg, n=10 per group) (middle panel); or mice subjected to cecal ligation puncture (CLP) procedure that were administered a solvent control or 30 mg/kg of I-BET twice a day for two days (n=8 per group) (right panel) b, Serum titers of indicated cytokines were measured by ELISA (n=10 per group). Mice received a solvent control (black squares) or I-BET (blue triangles) 1 hour before LPS injection and samples were collected at 2 hours after LPS treatment. *** p<0.001, ** p<0.01, *p<0.05 as determined by unpaired T test.