Table 4.
Multivariate analysis: predictors of PPI prescription at discharge among patients on combination aspirin and anticoagulation therapy.
| Characteristic | OR | 95% CI | p value |
|---|---|---|---|
| Patient age (years) | |||
| <60 | 1.0 | [ref] | [ref] |
| 60–69 | 1.61 | 1.17–2.23 | 0.0037 |
| 70–79 | 1.48 | 1.06–2.06 | 0.020 |
| ⩾80 | 1.12 | 0.81–1.60 | 0.45 |
| Sex | |||
| Male | 0.80 | 0.63–1.01 | 0.062 |
| Female | 1.0 | [ref] | [ref] |
| Race | |||
| White | 1.0 | [ref] | [ref] |
| African American | 0.73 | 0.48–1.10 | 0.13 |
| Other | 1.02 | 0.75–1.37 | 0.92 |
| Unknown | 0.74 | 0.52–1.04 | 0.084 |
| Insurance | |||
| Medicaid | 0.55 | 0.35–0.88 | 0.012 |
| Medicare | 0.71 | 0.51–0.97 | 0.034 |
| Commercial insurance | 1.0 | [ref] | [ref] |
| Self pay | 0.85 | 0.66–1.13 | 0.27 |
| Primary language | |||
| English | 1.0 | [ref] | [ref] |
| Spanish | 0.63 | 0.45–0.87 | 0.0049 |
| Other | 0.70 | 0.45–1.10 | 0.13 |
| Unknown | 1.21 | 0.71–2.04 | 0.48 |
| Marital status | |||
| Not married | 1.0 | [ref] | [ref] |
| Married | 1.21 | 0.95–1.55 | 0.12 |
| Aspirin dose at discharge | |||
| 81 mg | 0.40 | 0.31–0.53 | <0.0001 |
| 325 mg | 1.0 | [ref] | [ref] |
| Anticoagulation type | |||
| Oral | 1.0 | [ref] | [ref] |
| Parenteral | 0.84 | 0.63–1.10 | 0.20 |
| Oral + parenteral | 0.50 | 0.36–0.68 | <0.0001 |
| Discharged on antiplatelet* therapy | 0.77 | 0.55–1.08 | 0.13 |
| Discharged on steroid therapy | 1.16 | 0.84–1.61 | 0.37 |
| Discharged on antiplatelet + steroid therapy | 1.15 | 0.52–2.52 | 0.73 |
| PPI at admission | 120.03 | 75.06–191.92 | <0.0001 |
*
Antiplatelet drug category does not include aspirin.
CI, confidence interval; HR, hazard ratio; PPI, proton-pump inhibitor.