Table 1. Clinical characteristics of healthy volunteers, patients with AE-IIP, and patients with SD-IIP.
| Healthy Volunteers | Patients With SD-IIP | Patients With AE-IIP | P Value | |
|---|---|---|---|---|
| Subjects (n) | 45 | 62 | 56 | |
| Age (years) | 43±2*† | 68±1 | 70±1 | <0.01 |
| Gender (M/F) | 29/16 | 47/15 | 47/9 | 0.078 |
| IPF/non IPF (n) | NA | 33/29 | 21/35 | 0.063 |
| Duration from diagnosis to hospitalization for AE (months) | NA | NA | 24±4 | |
| Duration of symptoms before admission (days) | NA | NA | 9±1 | |
| Survivor /Non-survivor at 60 days after admission (n) | NA | NA | 25/31 | |
| Glucocorticoid pulse therapy (n) | NA | NA | 56 | |
| Cyclophosphamide pulse therapy (n) | NA | NA | 7 | |
| Sivelestat (n) | NA | NA | 23 | |
| WBC (/μl) | NA | 7907±315 | 10439±618 | 0.001 |
| LDH (IU/L) | NA | 260±8 | 450±56 | <0.001 |
| KL-6 (U/ml) | NA | 1463±144 | 1524±127 | 0.485 |
| SP-A (ng/ml) | NA | 98±8 | 119±7 | 0.012 |
| SP-D (ng/ml) | NA | 250±24 | 344±53 | 0.084 |
| CRP (mg/dl) | NA | 1.36±0.48 | 7.97±0.88 | <0.001 |
| ESR (mm/h) | NA | 28±3 | 39±4 | 0.012 |
| PCT (ng/ml) | NA | NA | 0.65±0.27 | |
| BNP (pg/ml) | NA | NA | 90.1±21.2 | |
| FBG (mg/dl) | NA | NA | 453±16 | |
| FDP (μg/ml) | NA | NA | 13.7±3.5 | |
| D-dimer (μg/ml) | NA | NA | 6.6±1.6 | |
| P/F on admission (mmHg) | NA | NA | 206±16 | |
| SIRS (+/-) | NA | NA | 34/22 | |
| SIRS score | NA | NA | 1.9±0.1 | |
| APACHE II score | NA | NA | 13.7±0.7 | |
| VC (L) | NA | 2.55±0.18 | NA | |
| %VC (%) | NA | 79.8±4.8 | NA | |
| Serum syndecan-4 (ng/ml) | 16.05±0.77 | 25.22±3.72*ǂ | 10.65±0.73 | <0.001 |
SD: stable disease, AE: acute exacerbation, IPF: idiopathic pulmonary fibrosis, WBC: white blood cell count, LDH: lactate dehydrogenase, KL-6: Krebs von den Lungen-6, SP-A: surfactant protein-A, SP-D: surfactant protein-D, CRP: c-reactive protein, ESR: erythrocyte sedimentation rate, PCT: procalcitonin, BNP: brain natriuretic peptide, FBG: fibrinogen, FDP: fibrin and fibrinogen degradation product, P/F: arterial partial pressure of carbon dioxide/Fraction of inspiratory oxygen, SIRS: systemic inflammatory response syndrome, VC: vital capacity. APACHE II score: acute physiology and chronic health evaluation II score.
* Healthy Volunteers vs Patients with SD-IIP.
†Healthy Volunteers vs Patients with AE-IIP.
ǂ Patients with SD-IIP vs Patients with AE-IIP. Mean ± SEM.