Figure 4.

Density for Fondaparinux in Its Complex with AAV-DJ Compared with Related Structures

(A) As in other panels, a standard difference map for fondaparinux at 5 Å resolution is shown at the 13 σ level in orange, the ligand is colored by atom type; the trace of the viral protein backbone (and arginines of the HBD) is colored green or purple for symmetry-equivalent subunits. (B) The higher-resolution (4 Å) difference map, shown at the 14 σ level, was not as readily interpretable. (C) Difference density at 7 σ from the 8.3 Å AAV-2/heparin complex is superimposed in pink.⁸ (D) The atomic model and map of the SOS complex are overlaid on the AAV-DJ structure as found in the fondaparinux complex (4.8 Å resolution; 7 σ; pink).⁹