Figure 2.

FKRP Gene Therapy Improves the Internal Structure and Hyper-/Hypotrophy of Skeletal and Cardiac Muscle Fibers

(A) Cross-sections from tibialis anterior, diaphragm, and heart tissue of AAV-treated and FKRP^P448L mutant mice stained with H&E. Scale bars, 100 μm. (B) Quantification of centrally nucleated fibers in AAV-treated and untreated FKRP^P448L mutant tibialis anterior muscles (n = 4). ***p ≤ 0.001 (Student’s t test, each condition versus age-matched FKRP^P448L mutant mice). (C) The equivalent radius of individual myofibers in tibialis anterior muscles from FKRP^P448L mutant mice injected with AAV9-FKRP (+) or untreated (−) for each cohort (n = 4).