Figure 3.

Gene Therapy with AAV9-FKRP Slows the Progression of Fibrosis in the Diaphragm

(A) Masson’s trichrome staining of diaphragm tissue of AAV-treated and FKRP^P448L mutant mice in each cohort. Scale bar, 200 μm. (B) Quantification of the fibrotic area of the diaphragm in AAV-treated and FKRP^P448L mutant mice for each cohort (n = 4). **p ≤ 0.01; ***p ≤ 0.001 (Student’s t test, each condition versus age-matched FKRP^P448L mutant mice).