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. 2017 Mar 1;5:11–19. doi: 10.1016/j.omto.2017.02.002

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Ad/TMZ, but Not TMZ/Ad, Treatment In Vivo Induces Enhanced Recognition of Glioma Cells by Peripheral T Cells

Splenocytes derived from non-treated (NT), Delta24-RGD (Ad), post-treated (Ad/TMZ), and pre-treated (TMZ/Ad) mice were cocultured with GL261 cells ex vivo, and supernatants were assessed for IFN-γ in triplicate as a measure of antigen recognition. Splenocytes from virus and post-treated mice, not pre-treated mice, produced significantly more IFN-γ 8 days after viral treatment (pi, black bars, *p < 0.05). Error bars indicate SD.