Figure 1.

Schematic Representation of the p53 Family Members Described in This Review

(A) Modifications of p53 to increase the WT p53 efficacy and counteract resistance of cancer cells to OV-p53 therapy. The different domains of WT p53 are shown. The amino acid residues substituted in some p53 mutants are shown in red, whereas the non-modified residues are indicated in black. (B) Schematic representation of p63 and p73 proteins, which share some domains with p53, but also contain the Sterile Alpha Motif (SAM) domain. The anti-apoptotic isoform of p73 (ΔTAp73) is overexpressed in metastatic melanomas, and it can oppose the proapoptotic functions of p53 and full-length p73. To counteract ΔTAp73, we used a transcriptionally active form of p73 (isoform TA-p73β). 11R, 11 polyarginine peptide; CC, coiled-coil; NLS, nuclear localization signal.