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. 2017 Mar 18;5:51–58. doi: 10.1016/j.omtm.2017.03.002

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© 2017 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Selective Killing of Tumorigenic hPSCs by a Novel Oncolytic Virus Strategy

Survivin-responsive m-CRAs (Surv.m-CRAs), whose replication is controlled by the survivin promoter upstream of the adenoviral early region 1A (E1A), are promising anticancer agents that effectively and specifically treat a variety of cancers. The m-CRA platform technology is also applicable to selective eradication of tumorigenic cells in hPSC populations. Pre-infection of hPSCs with Surv.m-CRA results in efficient viral replication and cytocidal potential in undifferentiated cells, but not in differentiated cells.