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. 2017 Mar 29;5:62–74. doi: 10.1016/j.omto.2017.03.003

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© 2017 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Enadenotucirev Does Not Show Appreciable Replication in Animal Cell Lines or Primary Cells

(A) AB22 (murine lung mesothelioma), BHK (baby hamster kidney fibroblast), CHO (Chinese hamster ovary epithelial), MDCK (cocker spaniel kidney epithelial), Rab9 (New Zealand white rabbit epithelial), Vero and BSC-1 (African green monkey kidney epithelial), and HT29 (human colorectal carcinoma) cells were exposed to a range of enadenotucirev concentrations. At 72 hr post infection, cell viability was measured by MTS assay. Data represent mean values ± SD (n = 3). (B) HT29 cells or a range of primary human or animal hepatocytes were exposed to enadenotucirev at ten particles per cell. At 72 hr post infection, cell monolayers were harvested, lysed, and viral genomes were quantified by qPCR. The data represent mean ± SD (n = 3).