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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: Cell Rep. 2017 Mar 28;18(13):3178–3191. doi: 10.1016/j.celrep.2017.03.009

Figure 2. Peripheral Nerve Anatomy and Function in Sh3tc2 and Nrcam Mutations.

Figure 2

(A–D) Montages of cross-sections of the motor branch of the femoral nerve from wild-type (A), Nrcam−/− (B), Sh3tc2−/− (C), and double-mutant (D) mice are shown.

(E) A cumulative histogram of axon diameters indicates no change in the single or double mutants.

(F) Cumulative histograms of myelin thickness reveal no change in Nrcam−/− nerves, a significant decrease in Sh3tc2−/− nerves, but no additional decrease in double-mutant nerves.

(G) Axon number was not changed in any genotype.

(H) NCV was reduced in Nrcam−/− mice, was reduced to a greater degree in Sh3tc2−/− mice, and was further reduced in double-mutant mice.

Data from eight mice per genotype are presented in (E)–(G); (H) includes ten control, 14 Nrcam−/−, ten Sh3tc2−/−, and 14 double-mutant mice. Values in (G) and (H) are mean ± SD. Mice were from 73 to 145 days old (average 104 days) in (E)–(G) and 57–125 days old (average 103 days) in (H). *p < 0.05, **p < 0.01. Scale bar in (D), 50 μm for (A)–(D).