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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Plant J. 2017 Mar 10;90(4):671–682. doi: 10.1111/tpj.13449

Figure 2. UPR-regulated Transcription Factors may Tailor UPR Activation to Specific Stress Combinations.

Figure 2

Several plant-specific transcription factors are upregulated under ER stress in an IRE1/bZIP28 dependent way. Two membrane-bound transcription factors, ANAC062 and ANAC089, have been shown to relocate to the nucleus under ER stress. ANAC062 also is nuclear localized under cold stress conditions. ANAC089 along with interactor PAS1 (PASTICCINO1) were also shown to relocate to the nucleus in roots treated with 1-naphthaleneacetic acid to induce dedifferentiation. ANAC103, a soluble transcription factor, was also shown to upregulate UPR genes upon over expression. Although truncated forms of these transcription factors were shown to upregulate UPR responsive genes, the molecular mechanisms of action of native transcription factors are still unknown. After upregulation by IRE1/bZIP28 dependent mechanisms, these transcription factors may respond to secondary signals which reinforce or alter UPR gene expression.