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. Author manuscript; available in PMC: 2018 May 2.
Published in final edited form as: Structure. 2017 Apr 13;25(5):739–749.e3. doi: 10.1016/j.str.2017.03.009

Figure 1. Locations and identities of mutations made across directed evolution trajectory of ubiquitin.

Figure 1

A) Table showing amino acid identities of mutation sites for the wild-type, core and affinity matured mutants. Blue coloring represents residue identities first introduced in the core mutant. Green shows new residue identities for the affinity matured mutations.

B) Wild-type ubiquitin (PDB ID: 1ubq) model shown in grey with spheres representing locations of mutation sites, colored as in panel A and labeled by residue number.