Table 3.
Association between CT characteristics and EGFR mutation status
| Variable | EGFR mutation status | P | Univariate OR | |
|---|---|---|---|---|
| Positive | Negative | |||
| Diameter (mm) | 19.35 ± 6.15 | 20.65 ± 7.33 | 0.215 | NA |
| Shape | ||||
| Round/oval | 78 | 55 | 0.428 | Reference |
| Irregular | 25 | 13 | 1.356 (0.638, 2.882) | |
| Border definition | ||||
| Well defined | 57 | 46 | 0.108 | Reference |
| Poorly defined | 46 | 22 | 1.687 (0.890, 3.199) | |
| Margins | ||||
| Smooth | 38 | 22 | 0.543 | Reference |
| Lobulated/spiculated | 65 | 46 | 0.818 (0.428, 1.562) | |
| Cavitation/bubble‐like lucency | ||||
| + | 25 | 16 | 0.911 | 1.042 (0.508, 2.138) |
| − | 78 | 52 | Reference | |
| Air bronchogram† | ||||
| + | 37 | 19 | 0.276 | 1.466 (0.743, 2.812) |
| − | 66 | 49 | Reference | |
| Thickening of the adjacent pleura | ||||
| + | 15 | 15 | 0.207 | 0.602 (0.273, 1.331) |
| − | 88 | 53 | Reference | |
| Pleural retraction | ||||
| + | 55 | 29 | 0.169 | 1.541 (0.831, 2.856) |
| − | 48 | 39 | Reference | |
| Vascular convergence | ||||
| + | 17 | 11 | 0.955 | 1.024 (0.447, 2.347) |
| − | 86 | 57 | Reference | |
| Lymphadenopathy | ||||
| + | 15 | 8 | 0.600 | 1.278 (0.510, 3.204) |
| − | 88 | 60 | Reference | |
| GGO proportion | ||||
| GGO negative | 61 | 53 | 0.039 | Reference |
| 0% < GGO ≤ 50% | 27 | 10 | — | 2.346 (1.040, 5.292) |
| 50% < GGO ≤ 100% | 15 | 5 | — | 2.607 (0.888, 7.652) |
| GGO presence | ||||
| GGO negative | 61 | 53 | 0.011 | Reference |
| Any GGO | 42 | 15 | 2.433 (1.214, 4.875) | |
| Lobe | ||||
| Upper lobes | 90 | 47 | 0.028 | 1.915 (1.071, 3.424) |
| Lower lobes | 36 | 36 | Reference | |
†
+ Air bronchogram present, − air bronchogram absent.
CI, confidence interval; CT, computed tomography; EGFR, epidermal growth factor receptor; GGO, ground‐glass opacity; NA, not applicable; OR, odds ratio.