Table 4.
Multivariable logistic regression analyses of CT features predicting the presence of EGFR mutation in lung adenocarcinoma
| Variable | P | Odds ratio | 95% CI |
|---|---|---|---|
| Shape | |||
| Round/oval | — | Reference | NA |
| Irregular | 0.807 | 1.3 | 0.366, 2.187 |
| Border definition | |||
| Well defined | — | Reference | NA |
| Poorly defined | 0.865 | 1.083 | 0.434, 2.700 |
| Margins | |||
| Smooth | — | Reference | NA |
| Lobulated/spiculated | 0.838 | 1.091 | 0.472, 2.520 |
| Cavitation/bubble‐like lucency | |||
| + | 0.843 | 1.008 | 0.474, 2.496 |
| − | — | Reference | NA |
| Air bronchogram | |||
| + | 0.260 | 1.584 | 0.711, 3.528 |
| − | — | Reference | NA |
| Thickening of the adjacent pleura | |||
| + | 0.443 | 0.715 | 0.303, 1.687 |
| − | — | Reference | NA |
| Pleural retraction | |||
| + | 0.176 | 1.607 | 0.809, 3.192 |
| − | — | Reference | NA |
| Vascular convergence | |||
| + | 0.771 | 1.145 | 0.461, 2.841 |
| − | — | Reference | NA |
| Lymphadenopathy | |||
| + | 0.298 | 1.696 | 0.627, 4.590 |
| − | — | Reference | NA |
| GGO proportion | |||
| GGO negative | — | Reference | NA |
| Any GGO | 0.030 | 2.746 | 1.101, 6.849 |
| Lobe | |||
| Upper lobes | 0.096 | 1.806 | 0.900, 3.624 |
| Lower lobes | — | Reference | NA |
CI, confidence interval; CT, computed tomography; EGFR, epidermal growth factor receptor; GGO, ground‐glass opacity; NA, not applicable.