Table 1.
NRF2-addicted cancer cell lines.
| Cell line | Cancer types | Causes for NRF2 activation | Reference |
|---|---|---|---|
| Lung | |||
| A549 | Adenocarcinoma | KEAP1 G333C (homo) | (47, 55) |
| KEAP1 promoter methylation | (50) | ||
| H838 | KEAP1 443 frameshift (homo) | (47) | |
| H1395 | KEAP1 G350S (hetero) | ||
| H1993 | |||
| H1435 | KEAP1 L413R (homo) | ||
| H460 | Large cell carcinoma | KEAP1 D236H (homo) | |
| Esophagus | |||
| KYSE70 | Squamous cell carcinoma | NRF2 W24C (homo) | (56) |
| KYSE110 | NRF2 E82D (hetero) | ||
| KYSE180 | NRF2 D77V (homo) | ||
| Kidney | |||
| Caki-2 | Clear cell carcinoma | p62 accumulation | (57) |
| KEAP1 silencing? | |||
| UMRC-2 | p62 accumulation | ||
| SK-RC-20 | Carcinoma | p62 accumulation | |
| UMRC-6 | p62 accumulation | ||
| SLR21 | KEAP1 silencing? | ||
| A498 | n.d. | (58) | |
| Pancreas | |||
| AsPC-1 | Adenocarcinoma | n.d. | (59) |
| Colo-357 | n.d. | (60) | |
| Suit-2 | KEAP1 silencing? | (61) | |
| Prostate | |||
| DU145 | Carcinoma | KEAP1 promoter methylation | (31) |
| Liver | |||
| JHH-5 | Hepatocellular carcinoma | n.d. | (62) |
| Huh1 | Phosphorylated p62 accumulation | ||
The number in the causes for NRF2 activation column indicates the position of the mutated amino acid. Frameshift generates stop codon. homo, homozygous (2 mutant alleles); hetero, heterozygous (1 mutant allele); n.d., not yet determined.