Table 1.
Concentrations used | Quantification method | |||||
---|---|---|---|---|---|---|
A | B | Drug | μg/ml | μM | ||
1 | PZQ | SQV | PZQ | 20 | 64 | HPLC |
SQV | 20 | 29.8 | ||||
2 | SQV | PZQ | [3H] SQV | 1.07 | Radiolabeled assay | |
PZQ | 20 | 64 | ||||
3 | IVM | SQV | [3H] IVM | 0.01 | Radiolabeled assay | |
SQV | 20 | 29.8 | ||||
4 | SQV | IVM | SQV | 20 | 29.8 | HPLC |
IVM | 20 | 22.75 | ||||
5 | PZQ | EFV | PZQ | 20 | 64 | HPLC |
EFV | 20 | 63.4 | ||||
6 | PZQ | NVP | PZQ | 20 | 64 | HPLC |
NVP | 20 | 75.1 | ||||
7 | IVM | NVP | [3H] IVM | 0.01 | Radiolabeled assay | |
NVP | 20 | 75.1 | ||||
8 | NVP | IVM | [3H] NVP | 1.5 | Radiolabeled assay | |
IVM | 20 | 22.75 | ||||
9 | IVM | LPV | [3H] IVM | 0.02 | Radiolabeled assay | |
LPV | 20 | 31.81 | ||||
10 | LPV | IVM | [3H] LPV | 1.5 | Radiolabeled assay | |
IVM | 20 | 22.75 | ||||
11 | IVM | EFV | [3H] IVM | 0.01 | Radiolabeled assay | |
EFV | 20 | 63.34 | ||||
12 | EFV | IVM | [14C] EFV | 0.01 | Radiolabeled assay | |
IVM | 20 | 22.75 |
Drug A Drug whose transport is under investigation
Drug B Interacting drug