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Primary neurulation. A: Thickening of embryonic ectoderm is seen dorsal to notochord to form neuroectoderm and neural plate; B: Neural plate invaginates along its central axis to form neural groove. Neural folds are formed on both sides of the neural groove; C: The neural plate then bends and neural folds fuse together to form neural tube and simultaneously separate from surface ectoderm (dysjunction).
