Table 3. Multivariable regression analysis of genetic risk scores with CD and UC outcomes.
| Phenotypic outcome | Ethnicity | Genetic risk score beta coefficient | R-squared | Permuted P value |
|---|---|---|---|---|
| Crohn's disease | ||||
| Age of diagnosis | Hispanics | −0.229 | 0.059 | 0.046 |
| NHW | −0.162 | 0.063 | 0.191 | |
| Age of symptom onset | Hispanics | −0.231 | 0.060 | 0.039 |
| NHW | −0.170 | 0.054 | 0.144 | |
| Location of disease | ||||
| Ileal disease | Hispanics | −0.026 | 0.047 | 0.184 |
| NHW | 0.031 | 0.035 | 0.126 | |
| Ileocolonic disease | Hispanics | −0.002 | 0.011 | 0.946 |
| NHW | −0.028 | 0.041 | 0.253 | |
| Colonic disease | Hispanics | 0.015 | 0.023 | 0.443 |
| NHW | −0.007 | 0.054 | 0.737 | |
| Isolated upper GI tract | Hispanics | 0.204 | 0.080 | 0.098 |
| NHW | −0.826 | 0.014 | 0.602 | |
| Crohn's behavior | ||||
| Stricturing | Hispanics | 0.023 | 0.022 | 0.233 |
| NHW | 0.022 | 0.017 | 0.274 | |
| Penetrating | Hispanics | 0.017 | 0.015 | 0.536 |
| NHW | −0.039 | 0.039 | 0.156 | |
| Perianal disease | Hispanics | 0.029 | 0.033 | 0.158 |
| NHW | −0.004 | 0.029 | 0.841 | |
| History of hospitalizations | Hispanics | 0.067 | 0.038 | 0.079 |
| NHW | −0.023 | 0.069 | 0.690 | |
| Abdominal surgeries | Hispanics | 0.026 | 0.036 | 0.050 |
| NHW | 0.011 | 0.013 | 0.317 | |
| Perianal surgeries | Hispanics | 0.049 | 0.026 | 0.082 |
| NHW | −0.007 | 0.016 | 0.786 | |
| Ulcerative colitis | ||||
| Age of diagnosis | Hispanics | 0.068 | 0.013 | 0.720 |
| NHW | 0.136 | 0.073 | 0.550 | |
| Age of symptom onset | Hispanics | 0.059 | 0.013 | 0.760 |
| NHW | 0.147 | 0.500 | 0.530 | |
| Location of disease | ||||
| Proctitis | Hispanics | 0.053 | 0.041 | 0.390 |
| NHW | −0.063 | 0.018 | 0.395 | |
| Left-sided colitis | Hispanics | 0.010 | 0.045 | 0.716 |
| NHW | −0.037 | 0.119 | 0.327 | |
| Pan-colitis | Hispanics | −0.014 | 0.046 | 0.592 |
| NHW | 0.051 | 0.132 | 0.175 | |
| History of hospitalizations | Hispanics | −0.077 | 0.020 | 0.270 |
| NHW | 0.108 | 0.066 | 0.150 | |
| Colectomy | Hispanics | −0.018 | 0.060 | 0.720 |
| NHW | 0.176 | 0.04 | 0.090 | |
CD, Crohn's disease; IBD, inflammatory bowel disease; NHW, non-hispanic whites; UC, ulcerative colitis.
Beta coefficient: the beta value is a measure of how strongly each predictor variable (in this case genetic risk score) influences the dependent variable (in this case IBD phenotype).
R-squared: is a number that indicates the proportion of the variance in the dependent variable (IBD phenotype) that is predictable from the independent variable (genetic risk score).
Bold means significant p-values (P<0.05).