Table 1. Major subtype of IPMN and their characteristics.
| Histologic subtype | Frequency | Morphologic subtype |
Geneticsa |
Immunostaining markers | Progression to invasion | Type of associated adenocarcinoma | ||
|---|---|---|---|---|---|---|---|---|
| KRAS | GNAS | RNF43 | ||||||
| Gastric type | 60–70% | MD << BD | 53–87% | 39–65% | ? | Muc1–, Muc2–, Muc5AC+, Muc6+ | Low | Tubular ≅classic PDA? |
| Intestinal type | 30–40% | MD >> BD | 40–46% | 48–83% | ? | Muc1–, Muc2+, Muc5AC+, Muc6– | High | Colloid |
| Overall | (100%) | MD < BD | 41–79% | 41–75% | 14–75% | |||
BD, branch-duct type; MD, main-duct type.
a
% of case with mutation.