Table 10.

Direct predictors found running DCL and chi-square test on Metabric data

	5-year breast death	5-year survival death	10-year breast death	10-year survival death	15-year breast death	15-year survival death
DCL_α=1	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos
DCL_α=1	• ER category	• ER category	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos

DCL_α=9	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos
DCL_α=9	• ER category	• ER category	• HER2 status	• Age at diagnosis	• Lymph nodes pos	• Lymph nodes pos

DCL_α=15	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos
DCL_α=15	• ER category	• ER category	• HER2 status	• Age at diagnosis	• Lymph nodes pos	• Lymph nodes pos

DCL_α=54	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos
	• ER category	• ER category	• HER2 status	• Age at diagnosis	• Overall grade	• Age at diagnosis
						• Inferred menopausal status

DCL_α=108	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos
	• ER category	• ER category	• HER2 status	• Age at diagnosis	• Histological type	• Histological type
	• PR category	• Age at diagnosis	• PR category

Chi-square	• Age at diagnosis	• Age at diagnosis	• Age at diagnosis	• Age at diagnosis	• Age at diagnosis^*	• Age at diagnosis
	• Size	• Size	• Size	• Size	• Size	• Size^*
	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos	• Lymph nodes pos
	• Overall grade	• Overall grade	• Overall grade	• Overall grade	• Overall grade	• PR category^*
	• Histological type^*	• Histological type^*	• Histological type^*	• Histological type^*	• ER category	• HER2 status
	• ER category	• ER category	• ER category	• ER category	• PR category	• Inferred menopausal status^*
	• PR category	• PR category	• PR category	• PR category	• HER2 status	• Percent nodes positive
	•HER2 status	• HER2 status	• HER2 status	• HER2 status	• Percent nodes positive
	•Inferred menopausal status	• Percent nodes positive	• Axillary nodes removed^*	• Inferred menopausal status
	• Percent nodes positive		• Percent nodes positive	• Axillary nodes removed^*
				• Percent nodes positive

significant at α = 0.05 but not α = 0.01

Blue- predictor not found in the previous alpha level for the same dataset

Red- predictor not found in the previous time-point (e.g. found in 10 year but not in 5 year)

Purple- Both red and blue conditions occur