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. 2017 Mar 14;7:61–70. doi: 10.1016/j.omtn.2017.03.003

Figure 2.

Figure 2

In Vivo Inhibition of Mef2a by GSO-Mef2a

(A) Immunohistochemical staining of MEF2A in the adductor muscle of GSO-Mef2a- and GSO-control-treated mice. (B) mRNA expression of Mef2a in the adductor muscle of C57BL/6 mice treated with GSO-Mef2a or GSO-control, 14 days after double ligation of the left femoral artery. Per group, adductor muscle tissue of ten animals was used. (C) Expression of Mef2a in the gastrocnemius muscle of C57BL/6 mice treated with GSO-Mef2a or GSO-control, 14 days after ischemia induction. Per group, gastrocnemius muscle tissue of ten animals was used. Mean expression levels relative to HPRT are shown here (±SEM). (D) MEF2A and actin protein expression and quantification in adductor muscle lysates of GSO-Mef2a- (M) and GSO-control (C)-treated mice (n = 2 animals per group). Mean expression as a percentage of control is shown here (±SEM). ***p < 0.001; ****p < 0.0001.