Table 4. SRS subscales attenuations by bumetanide.

Restricted interests and repetitive behavior	Bumetanide 0.5 mg b.i.d.	Bumetanide 1.0 mg b.i.d.	Bumetanide 2.0 mg b.i.d.	Placebo
n	20	18	13	21
Mean value	−1.70	−4.37	−5.78	+0.20
s.d.	5.72	4.37	4.98	4.15
Median value	−1.50	−3.50	−4.00	0.00

Social communication	Bumetanide 0.5 mg b.i.d.	Bumetanide 1.0 mg b.i.d.	Bumetanide 2.0 mg b.i.d.	Placebo
n	20	18	12	21
Mean value	−4.38	−3.09	−9.20	−1.25
s.d.	8.84	8.95	7.61	6.72
Median value	−4.5	−4.5	−11.0	−0.5

Statistically significant attenuations of Social Responsive Scale (SRS) subscales by bumetanide. The difference between treated and placebo were statistically different in social communication (Kuskaal–Wallis test P=0.03) and restricted interest and repetitive behavior (Kuskaal–Wallis test P=0.002).