Table 3. Pathway analysis of the risk genes for BD.
| Canonical pathways | P-value | Overlap | Genes |
|---|---|---|---|
| Glucocorticoid receptor signaling | 1.94E−03 | 4/270 (0.015) | MED1, GTF2A1, HSPA1L, TAF15 |
| Glutamine biosynthesis I | 1.98E−03 | 1/1 (1) | GLUL |
| Estrogen receptor signaling | 2.07E−03 | 3/128 (0.023) | MED1, GTF2A1, TAF15 |
| β-alanine degradation I | 3.96E−03 | 1/2 (0.5) | ALDH6A1 |
| Assembly of RNA polymerase II complex | 4.42E−03 | 2/50 (0.04) | GTF2A1, TAF15 |
| Protein ubiquitination pathway | 1.38E−02 | 3/254 (0.012) | NADJC7, HSP1L, UBE2E1 |
| Xenobiotic metabolism signaling | 1.41E−02 | 3-256 (0.012) | MED1, ALDH6A1, DNAJC7 |
| Oleate biosynthesis II (animals) | 1.97E−03 | 1/10 (0.1) | ALDH6A1 |
| Aryl hydrocarbon receptor signaling | 2.94E−02 | 2/135 (0.015) | MED1, ALDH6A1 |
| Valine degradation I | 3.51E−02 | 1/18 (0.056) | ALDH6A1 |
| Aldosterone signaling in epithelial cells | 3.60E−02 | 2/151 (0.013) | DNAJC7, HSPA1L |
| DNA methylation and transcriptional repression signaling | 3.90E−02 | 1/20 (0.05) | ARID4B |
| B-cell development | 4.47E−02 | 1/23 (0.043) | IL7R |
Abbreviation: BD, bipolar disorder.