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. 2017 Mar 7;7(3):e1054. doi: 10.1038/tp.2017.34

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Copyright © 2017 The Author(s)

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(a) Significant group-by-treatment-by-condition interaction in the right amygdala (MNI coordinates: x,y,z: 26,2,−24; z-score=2.66; P=0.032). (b) On placebo, the control and alcohol groups showed increased activation to aversive relative to neutral images, whereas the alcohol/drugs groups showed increased activation to all visual images, irrespective of emotional valence. (c) Naltrexone normalized activation in the alcohol/drugs group, such that activation was higher to aversive relative to neutral images, but did not change the pattern of activation in the control or alcohol groups. MNI, Montreal Neurological Institute.