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. 2017 Apr 4;7(4):e1077. doi: 10.1038/tp.2017.24

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Anhedonic behaviours in mice lacking the LPA1 receptor. (a) In the saccharin preference test, maLPA1-null mice displayed a preference below the anhedonic threshold set at 65% in all doses, showing significant differences from the preference of wt mice (n=7 per genotype). (b) Chronic desipramine treatment leads to improvement in motivation of maLPA1-null animals reaching levels above the anhedonic threshold (c) In female urine sniffing tests, maLPA1-null mice exhibited a significant reduction of the percentage of time sniffing oestrogenic female urine compared to wt animals (n= 6 per genotype). *P<0.05 time compared with wt. ^#P<0.05 time spent sniffing urine versus water. DMI, desipramine; FUST, female urine sniffing test; SPT, saccharin preference test.