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. 2017 Apr 4;7(4):e1077. doi: 10.1038/tp.2017.24

Figure 3.

Figure 3

Mice lacking the LPA1 receptor showed altered stress-coping behaviour (FST and TST) together with fear and anxiety (ETM). (a) MaLPA1-null mice exhibited reduced immobility and increased climbing compared to wt mice. The behavioural patterns differed between the two genotypes for all tests (n=7 per genotype). (b) In TST, maLPA1-null mice exhibited lower immobility and higher energy and PM levels than the control group (n=8 per genotype). (c) Compared with the wt mice, maLPA1-null mice showed higher baseline avoidance in the ETM, indicating anxiety-like behaviour, without habituating during the test. In the third trial of the escape test, they took more time to leave the open arm, which is associated with the high proportion of freezing time (n=9 per genotype). *P<0.05 **P<0.01 ***P<0.001 difference from wt; #P<0.05 or &P<0.05 difference between time points in wt or maLPA1-null mice, respectively. ETM, elevated T-maze; FST, forced swim test; Imm, immobility; TST, tail suspension test.