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. 2017 Apr 11;7(4):e1091. doi: 10.1038/tp.2017.45

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Multilocus DRD2 SNP effects on BP_ND. C957T T+Ins/Ins score (alone on left, displayed in hot yellow colors) and C957T T+Ins/Ins+Taq1A A2 dose score (center, displayed in cool colors) effects on Fallypride BP_ND are displayed as T-scores. Beyond the striatum, the C957T T+Ins/Ins multilocus score affects BP_ND in midbrain/thalamus and midbrain/pons (evident in coronal and saggital slices). The addition of A2 dosage information does not alter the multilocus score's relationship to striatal and thalamic BP_ND appreciatively (overlap of both multilocus effects in white/pink). Taq1A A2 dose also has no effect on the deeper midbrain/pons genetic effect observed with the C957T+Ins/Ins multilocus score (see saggital slice). Data are displayed using a P<0.005, uncorrected threshold. BP_ND, nondisplaceable binding potential; SNP, single-nucleotide polymorphism.