Table 2. Pathway analysis findings for 697 upregulated genes differentially expressed by affection status.

Category	GO ID	GO term	Fold enrichment	FDR
Biological process	GO:0006955	Immune response	2.38	2.00E−06
Biological process	GO:0009615	Response to virus	4.59	5.71E−04
Biological process	GO:0006916	Anti-apoptosis	3.24	2.50E−03
Biological process	GO:0050670	Regulation of lymphocyte proliferation	4.69	1.33E−02
Biological process	GO:0070663	Regulation of leukocyte proliferation	4.63	1.52E−02
Biological process	GO:0032944	Regulation of mononuclear cell proliferation	4.63	1.52E−02
Biological process	GO:0050867	Positive regulation of cell activation	4.00	1.74E−02
Biological process	GO:0042129	Regulation of T-cell proliferation	5.38	1.97E−02
Biological process	GO:0042110	T-cell activation	3.75	1.99E−02
Biological process	GO:0042981	Regulation of apoptosis	1.87	2.28E−02
Biological process	GO:0042127	Regulation of cell proliferation	1.87	2.56E−02
Biological process	GO:0002684	Positive regulation of immune system process	2.80	2.86E−02
Biological process	GO:0043067	Regulation of programmed cell death	1.85	2.97E−02
Biological process	GO:0010941	Regulation of cell death	1.84	3.34E−02
Biological process	GO:0050671	Positive regulation of lymphocyte proliferation	5.56	3.95E−02
Biological process	GO:0032946	Positive regulation of mononuclear cell proliferation	5.46	4.66E−02
Biological process	GO:0070665	Positive regulation of leukocyte proliferation	5.46	4.66E−02
Cellular component	GO:0009986	Cell surface	2.43	3.30E−02
Cellular component	GO:0005829	Cytosol	1.62	3.79E−02

Abbreviations: DAVID, Database for Annotation, Visualization and Integrated Discovery; FDR, false discovery rate; GO, gene ontology.

Note: GO terms are tabulated only for those showing FDR<0.05 for fold enrichment. The input into the DAVID tools analysis was the list of 697 genes differentially expressed by affection status (Bonferroni P<0.05) that were expressed at higher levels in the schizophrenia cases.