Table 2. Summary of the effects of adolescent stress on hippocampal-related cognitive behaviours in rodent models.
| Stressor | Species | Sex |
Age (PND) at |
Cognitive test | Cognitive effect | Reference | |
|---|---|---|---|---|---|---|---|
| Stress | Testing | ||||||
| Elevated platform | Wistar rat | M | 26–28 | 60 | MWM | ↓ Learning | Avital et al.97 |
| 28 | 90 | MWM | ↑ Reversal | ||||
| Tailshock | SD rat | M | ~27 | ~27–28 | TEC | ↔ Responses | Hodes et al.94 |
| ~37 | ~37–38 | TEC | ↑ Responses | ||||
| Tailshock | SD rat | F | ~27 | ~27–28 | TEC | ↔ Responses | |
| ~37 | ~37–38 | TEC | ↑ Responses | ||||
| Chronic mild | SD rat | M | 30–70 | ~385 | RAM | ↔ Latency | Chaby et al.98 |
| Chronic mild | SD rat | M | ~43–63 | ~64–67 | TFC | ↑ Freezing | Reich et al.99 |
| ~64–67 | DFC | ↔ Freezing | |||||
| Chronic physical | SD rat | M | 28–55 | 56 | MWM | ↔ Learning | Isgor et al.73 |
| 28–55 | 76 | MWM | ↓ Learning | ||||
| Chronic social | SD rat | M | 28–55 | 56 | MWM | ↔ Learning | |
| 28–55 | 76 | MWM | ↔ Learning | ||||
| Chronic social | CD1 mouse | M | ~32–80 | ~270 | MWM | ↔ Learning | Sterlemann et al.77 |
| ~440 | MWM | ↓ Learning | |||||
| ~440 | Y-Maze | ↓ Learning | |||||
| ~440 | NOR | ↔ Recognition | |||||
| ~440 | SDL | ↔ Recognition | |||||
| Social instability | LE rat | F | 30–45 | 46–48 | SLR | ↔ Memory | McCormick et al.70 |
| 70–72 | SLR | ↓ Memory | |||||
| Social instability | LE rat | M | 30–45 | 46–49 | SLR | ↔ Memory | McCormick et al.69 |
| 46–49 | NOR | ↔ Recognition | |||||
| 70–73 | SLR | ↓ Memory | |||||
| 70–73 | NOR | ↔ Recognition | |||||
| Social isolation | ICR mouse | M | 24–59 | 53–59 | MWM | ↓ Learning | Ibi et al.71 |
| Social isolation | LH rat | M | ~28–58 | ~58 | NOR | ↓ Recognition | Bianchi et al.96 |
| Social isolation | LH rat | F | 28–70 | ~70 | NOR | ↓ Recognition | McLean et al.100 |
| ~70 | AS | ↓ Learning | |||||
| Variable | SD rat | M | 27–29 | 59–60 | TWS | ↓ Avoidance | Tsoory et al.101 |
| 33–35 | 59–60 | TWS | ↓ Avoidance | ||||
| Variable | SD rat | M | 27–29 | 60–61 | TWS | ↓ Avoidance | Ilin et al.102 |
| Variable | SD rat | M | 27–29 | 63 | TWS | ↓ Avoidance | Tsoory et al.103 |
| Variable | WH rat | M | 28–30 | 41–42 | CFC | ↔ Freezing | Toledo-Rodriguez et al.95 |
| 41–42 | AFC | ↑ Freezing | |||||
| 83–87 | CFC | ↔ Freezing | |||||
| 83–87 | AFC | ↑ Freezing | |||||
| Variable | WH rat | F | 28–30 | 41–42 | CFC | ↓ Freezing | |
| 41–42 | AFC | ↔ Freezing | |||||
| 83–87 | CFC | ↔ Freezing | |||||
| 83–87 | AFC | ↔ Freezing | |||||
Abbreviations: AFC, auditory fear-conditioning; AS, attentional set-shifting; CFC, contextual fear-conditioning; DFC, delay fear-conditioning; F, female; ICR, Institute for Cancer Research; LE, long-Evans; LH, lister hooded; M, male; MWM, Morris water maze; NOR, novel object recognition; PND, post-natal day; RAM, radial arm maze; SD, Sprague–Dawley; SDL, social discrimination learning; SLR, spatial location recognition; TEC, trace eyeblink conditioning; TFC, trace fear-conditioning; TWS, two-way shuttlebox; WH, Wistar Han.