Table 3. Survival analysis for age of depression onset (GS:SFHS) or diagnosis (UKB) and polygenic risk for Alzheimer's disease, from Cox proportional hazards model. Results are shown at five different P-value thresholds.
| AD PGRS P-value threshold |
GS:SFHS |
UKB |
||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P-valuea | Hazard ratio | 95% CI | P-valuea | |
| ⩽0.01 | 0.999 | 0.938, 1.063 | 9.75 × 10−1 | 1.014 | 0.972, 1.058 | 5.23 × 10−1 |
| ⩽0.05 | 0.992 | 0.931, 1.056 | 7.91 × 10−1 | 0.984 | 0.943, 1.028 | 4.73 × 10−1 |
| ⩽0.10 | 0.986 | 0.926, 1.049 | 6.49 × 10−1 | 0.994 | 0.952, 1.037 | 7.70 × 10−1 |
| ⩽0.50 | 0.976 | 0.917, 1.038 | 4.39 × 10−1 | 0.988 | 0.947, 1.032 | 5.91 × 10−1 |
| ⩽1.00 | 0.969 | 0.910, 1.031 | 3.15 × 10−1 | 0.986 | 0.945, 1.030 | 5.33 × 10−1 |
Abbreviations: AD, Alzheimer's disease; CI, confidence interval; GS:SFHS, Generation Scotland's Scottish Family Health Study; PGRS, polygenic risk scores; UKB, UK Biobank.
a
P-values shown are uncorrected for multiple testing.