Table 4. Associations between polygenic risk scores for AD and early-onset depression status, and AD PGRS and late-onset depression, at five different P-value thresholds in the GS:SFHS and UKB samples.
| AD PGRS P-value threshold |
GS:SFHS |
UKB |
||||
|---|---|---|---|---|---|---|
| Beta | 95% CI | P-valuea | Beta | 95% CI | P-valuea | |
| First quartile of age of onset | ||||||
| ⩽0.01 | 0.001 | −0.023, 0.024 | 9.16 × 10−1 | 0.026 | −0.063, 0.115 | 5.64 × 10−1 |
| ⩽0.05 | 0.001 | −0.023, 0.024 | 9.38 × 10−1 | 0.019 | −0.070, 0.109 | 6.73 × 10−1 |
| ⩽0.10 | 0.001 | −0.023, 0.024 | 9.23 × 10−1 | 0.007 | −0.083, 0.097 | 8.82 × 10−1 |
| ⩽0.50 | −0.008 | −0.032, 0.016 | 4.84 × 10−1 | −0.021 | −0.110, 0.069 | 6.54 × 10−1 |
| ⩽1.00 | −0.007 | −0.031, 0.017 | 5.40 × 10−1 | −0.028 | 0.118, 0.062 | 5.37 × 10−1 |
| Fourth quartile of age of onset | ||||||
| ⩽0.01 | 0.013 | −0.022, 0.048 | 4.51 × 10−1 | 0.020 | −0.069, 0.109 | 6.56 × 10−1 |
| ⩽0.05 | 0.016 | −0.019, 0.051 | 3.78 × 10−1 | −0.039 | −0.128, 0.051 | 4.00 × 10−1 |
| ⩽0.10 | 0.008 | −0.027, 0.043 | 6.49 × 10−1 | −0.025 | −0.114, 0.065 | 5.91 × 10−1 |
| ⩽0.50 | −0.004 | −0.039, 0.032 | 8.60 × 10−1 | 0.007 | −0.082, 0.096 | 8.77 × 10−1 |
| ⩽1.00 | −0.006 | −0.041, 0.029 | 7.40 × 10−1 | 0.012 | −0.077, 0.101 | 7.86 × 10−1 |
| MDD onset over 40 years | ||||||
| ⩽0.01 | 0.013 | −0.022, 0.048 | 4.51 × 10−1 | 0.002 | −0.057, 0.061 | 9.53 × 10−1 |
| ⩽0.05 | 0.016 | −0.019, 0.051 | 3.78 × 10−1 | −0.032 | −0.091, 0.027 | 2.91 × 10−1 |
| ⩽0.10 | 0.008 | −0.027, 0.043 | 6.49 × 10−1 | −0.013 | −0.072, 0.046 | 6.62 × 10−1 |
| ⩽0.50 | −0.004 | −0.039, 0.032 | 8.60 × 10−1 | −0.019 | −0.078, 0.041 | 5.35 × 10−1 |
| ⩽1.00 | −0.006 | −0.041, 0.029 | 7.40 × 10−1 | −0.015 | −0.074, 0.044 | 6.13 × 10−1 |
| MDD onset under 41 years | ||||||
| ⩽0.01 | −0.020 | −0.058, 0.019 | 3.20 × 10−1 | 0.0016 | −0.056, 0.087 | 6.63 × 10−1 |
| ⩽0.05 | 0.001 | −0.038, 0.039 | 9.55 × 10−1 | −0.015 | −0.087, 0.057 | 6.83 × 10−1 |
| ⩽0.10 | 0.007 | −0.031, 0.045 | 7.30 × 10−1 | −0.019 | −0.091, 0.053 | 6.09 × 10−1 |
| ⩽0.50 | −0.004 | −0.043, 0.034 | 8.16 × 10−1 | −0.031 | −0.102, 0.041 | 4.06 × 10−1 |
| ⩽1.00 | −0.004 | −0.043, 0.034 | 8.25 × 10−1 | −0.039 | −0.111, 0.033 | 2.90 × 10−1 |
Abbreviations: AD, Alzheimer's disease; CI, confidence interval; GS:SFHS, Generation Scotland's Scottish Family Health Study; MDD, major depressive disorder; PGRS, polygenic risk scores; UKB, UK Biobank.
a
P-values shown are uncorrected for multiple testing.