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. 2017 Apr 4;7(4):e1082. doi: 10.1038/tp.2017.52

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Copyright © 2017 The Author(s)

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Gene regulation by Tcf4 and its interaction partners. (a) Gene Ontology (GO) analysis of putative Tcf4 target genes. Ranking is by Bonferroni-corrected P-value. P-value (as −log10) and number of Tcf4 target genes in each category is indicated. (b and d) Regulation of primary microcephaly genes by Tcf4 (b) or by Smad4 (d), Relative mRNA levels by RT-PCR of indicated genes in NSCs treated with the indicated shRNAs, s.e.m. of three independent experiments is indicated. (c) Interaction network of Tcf4 with network transcription factors that are associated with microcephaly. (e) Binding site profile of indicated transcription factors and indicated histone modification profiles at Mcph1 (upper panel) or Wdr62 (lower panel). Angpt2, internal to Mcph1 and not regulated by Tcf4, is not indicated. Ep300, H3K4me1 mark enhancers, H3K27ac marks active enhancers, arrows mark transcription factor co-localization. mRNA, messenger RNA; NSC, neural stem cell; shRNA, short hairpin RNA.