Table 4. Anterior cingulate cortex glutamate effects on fMRI response to emotional stimuli (Emotional>Neutral contrast; region of interest analysis).

Brain region	Side	MNI			Number of voxels	Z-score	P-value FWE
		x	y	z
Correlation in HS subjects
Positive
No suprathreshold effect
Negative
Caudate	L	−20	4	20	695	4.30	0.004
Putamen	L	−20	-	10		3.89	0.018
Caudate	R	16	0	20	759	4.12	0.008
Medial prefrontal cortex	R	4	64	26	107	3.55	0.052
Amygdala	L	−10	0	−12	12	2.88	0.062
	R	28	−8	−12	8	2.79	0.079
Correlation in LS subjects
Positive
No suprathreshold effect
Negative
No suprathreshold effect
Group × ACC glutamate interaction
Caudate	L	−14	16	14	275	3.44	0.040
	R	16	6	24	120	3.35	0.051

Abbreviations: ACC, anterior cingulate cortex; FWE, family-wise error correction; HS, high schizotypy; L, left; LS, low schizotypy; MNI, Montreal Neurological Institute; R, right.

P-value after voxel-wise FWE.