Table 1. Sociodemographic, medication use and prefrontal cortical thickness measures according to the presence of A allele CACNA1C rs1006737.
|
BD |
|||
|---|---|---|---|
| rs1006737 | Without A (N=67) | With A (N=50) | Sig. (two-tailed) |
| Age | 32.7±8.7 | 31.5±10.2 | P=0.1 |
| Gender (female/male) | 49/18 | 29/21 | χ2=0.08 |
| Dexterity (n; right/left) | 58/9 | 42/8 | χ2=0.69 |
| Education (years) | 13.3±3.5 | 13.1±2.6 | P=0.3 |
| Illness duration (years) | 7.46±7.1 | 6.18±5.42 | P=0.35 |
| Lithium use (yes/no) | 44/23 | 42/8 | χ2=0.02 |
| Anticonvulsants use (yes/no) | 23/44 | 14/36 | χ2=0.46 |
| Antipsychotics use (yes/no) | 30/37 | 14/36 | χ2=0.06 |
| Antidepressants use (yes/no) | 10/57 | 4/46 | χ2=0.25 |
| Intracranial volume (mean±s.d.)a | 1 319 411±279 256 | 1 317 830±209 098 | P=0.26 |
| Right mOFC (mean±s.d.)a | 2.48±0.16 | 2.54±0.21 | P=0.01 |
| Right sFC (mean±s.d.)a | 2.52±0.15 | 2.56±0.18 | P<0.001 |
| Right rACC (mean±s.d.)a | 2.97±0.18 | 3.01±0.26 | P=0.08 |
| Right cACC (mean±s.d.)a | 2.63±0.24 | 2.70±0.29 | P=0.86 |
| Left mOFC (mean±s.d.)a | 2.41±0.16 | 2.51±0.16 | P=0.005 |
| Left sFC (mean±s.d.)a | 2.51±0.15 | 2.56±0.20 | P<0.001 |
| Left rACC (mean±s.d.)a | 2.98±0.19 | 2.98±0.22 | P=0.009 |
| Left cACC (mean±s.d.)a | 2.65±0.25 | 2.66±0.29 | P=0.11 |
Abbreviations: BD, bipolar disorder; cACC, caudal anterior cingulate cortex; mOFC, medial orbitofrontal cortex; rACC, rostral anterior cingulate cortex; sFC, superior frontal cortex.
a
Mean and s.d. without adjust for age and gender.