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. 2017 Apr 25;7(4):e1101. doi: 10.1038/tp.2017.68

Figure 5.

Figure 5

Anxiety-like behaviour and behavioural despair are not robustly affected by TMZ. (a and b) Open-field test—TMZ treatment does not affect locomotion (a) or the time spent in the centre suggesting no effect on anxiety-like behaviour (b). (c and d) Elevated plus maze—this same tendency was reflected in the elevated plus maze where there were no differences in the time spent in (c), nor entries into (d) the open arms. (e) Tail suspension test—no significant differences between treatment groups suggesting no effects on behavioural despair. (f) Forced swim test—no significant difference in TMZ mice verifying lack of effect on behavioural despair. EPM, elevated plus maze; OFT, open-field test; TMZ, temozolomide.