Table 1. Carrier status-dependent functional, gray and white matter volume changes.
| Hemisphere | MNI coordinates (x,y,z) | Effect (%) 95% CI | P-value (corrected) | Brodmann area | |
|---|---|---|---|---|---|
| sMRI: gray matter | |||||
| Fusiform gyrus | Left | (−35, −36, −15) | +3.0 (2.9, 3.1) | 0.045 | BA37 |
| Superior occipital | Left | (−22, −78, 24) | −4.8 (−5.0, −4.6) | 0.016 | BA19 |
| Superior frontal | Right | (20, 30, 52) | −5.0 (−5.2, 4.8) | 0.016 | BA8 |
| sMRI: white matter | |||||
| Cerebellum cruz 1 | Right | (28, −72, −32) | +7.7 (7.6, 7.9) | 6.84 × 10−5 | |
| Paracentral lobule | Right | (10, −30, 54) | +4.6 (4.5, 4.7) | 6.93 × 10−4 | |
| Superior temporal | Left | (−52, −12, 13) | +5.0 (4.5, 5.1) | 1.94 × 10−3 | |
| Anterior corpus callosum | NA | (4, 0, 22) | −4.6 (−4.7, −4.5) | 6.84 × 10−4 | |
| Amygdala | Right | (26, 2, −17) | −4.7 (−4.8, −4.6) | 5.57 × 10−3 | |
| fMRI word paradigm: PW vs W | |||||
| Fusiform gyrus | Left | (−28, −36, −14) | +68.2 (63.7, 72.8) | 0.007a | BA37 |
| fMRI multiplication paradigm: C vs F | |||||
| Angular gyrus | Left | (−50, −66, 24) | +87.2 (80.8, 93.8) | 2.08 × 10−4a | BA39 |
Abbreviations: C, correct equation; CI, confidence interval; F, false equation; fMRI, functional MRI; MNI, Montreal Neurological Institute; MRI, magnetic resonance imaging; NA, not available; PW, phonologically and orthographically unfamiliar forms; sMRI, structural brain MRI; W, orthographic familiar forms of Icelandic nouns.
a
P-values marked with a are corrected with respect to a region of interest (the left occipito-temporal lobe and the left parietal lobe).