Table 1.
Select works illustrating effects of oxygen on skeletal cells.
| Measuring Oxygen at the Fracture Site | References |
|---|---|
| C.T. Brighton, R.B. Heppenstall, and D.A. Labosky, An oxygen microelectrode suitable for cartilage and cancellous bone. Clin Orthop Relat Res 80 (1971) 161-6. | Brighton et al., 1971 |
| C.T. Brighton, and A.G. Krebs, Oxygen tension of nonunion of fractured femurs in the rabbit. Surg Gynecol Obstet 135 (1972) 379-85. | Brighton and Krebs, 1972 |
| C. Lu, M. Rollins, H. Hou, H.M. Swartz, H. Hopf, T. Miclau, and R.S. Marcucio, Tibial fracture decreases oxygen levels at the site of injury. Iowa Orthop J 28 (2008) 14-21. | Lu et al., 2008b |
| Lu, N. Saless, X. Wang, A. Sinha, S. Decker, G. Kazakia, H. Hou, B. Williams, H.M. Swartz, T.K. Hunt, T. Miclau, and R.S. Marcucio, The role of oxygen during fracture healing. Bone 52 (2013) 220-9. | Lu et al., 2013 |
| EFFECT OF OXYGEN ON FRACTURE HEALING | |
| R.B. Heppenstall, C.W. Goodwin, and C.T. Brighton, Fracture healing in the presence of chronic hypoxia. J Bone Joint Surg Am 58 (1976) 1153-6. | Heppenstall et al., 1976 |
| Lu, N. Saless, X. Wang, A. Sinha, S. Decker, G. Kazakia, H. Hou, B. Williams, H.M. Swartz, T.K. Hunt, T. Miclau, and R.S. Marcucio, The role of oxygen during fracture healing. Bone 52 (2013) 220-9. | Lu et al., 2013 |
| EFFECT OF OXYGEN ON STEM CELLS | |
| W.L. Grayson, F. Zhao, B. Bunnell, and T. Ma, Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun 358 (2007) 948-53. | Grayson et al., 2007 |
| P. Malladi, Y. Xu, M. Chiou, A.J. Giaccia, and M.T. Longaker, Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Am J Physiol Cell Physiol 290 (2006) C1139-46. | Malladi et al., 2006 |
| L.F. Raheja, D.C. Genetos, A. Wong, and C.E. Yellowley, Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1alpha. Cell Biol Int 35 (2011) 981-9. | Raheja et al., 2011 |
| A. Wong, E. Ghassemi, and C.E. Yellowley, Nestin expression in mesenchymal stromal cells: regulation by hypoxia and osteogenesis. BMC Vet Res 10 (2014) 173. | Wong et al., 2014 |
| C.C. Tsai, T.L. Yew, D.C. Yang, W.H. Huang, and S.C. Hung, Benefits of hypoxic culture on bone marrow multipotent stromal cells. Am J Blood Res 2 (2012) 148-59. | Tsai et al., 2012 |
| EFFECT OF OXYGEN ON OSTEOBLASTS | |
| D. Wu, J. Malda, R. Crawford, and Y. Xiao, Effects of hyperbaric oxygen on proliferation and differentiation of osteoblasts from human alveolar bone. Connect Tissue Res 48 (2007) 206-13. | Wu et al., 2007 |
| S.M. Warren, D.S. Steinbrech, B.J. Mehrara, P.B. Saadeh, J.A. Greenwald, J.A. Spector, P.J. Bouletreau, and M.T. Longaker, Hypoxia regulates osteoblast gene expression. J Surg Res 99 (2001) 147-55. | Warren et al., 2001 |
| D.S. Steinbrech, B.J. Mehrara, P.B. Saadeh, J.A. Greenwald, J.A. Spector, G.K. Gittes, and M.T. Longaker, Hypoxia increases insulinlike growth factor gene expression in rat osteoblasts. Ann Plast Surg 44 (2000) 529-34; discussion 534-5. | Steinbrech et al., 2000 |
| D.S. Steinbrech, B.J. Mehrara, P.B. Saadeh, G. Chin, M.E. Dudziak, R.P. Gerrets, G.K. Gittes, and M.T. Longaker, Hypoxia regulates VEGF expression and cellular proliferation by osteoblasts in vitro. Plast Reconstr Surg 104 (1999) 738-47. | Steinbrech et al., 1999 |
| O.C. Tuncay, D. Ho, and M.K. Barker, Oxygen tension regulates osteoblast function. Am J Orthod Dentofacial Orthop 105 (1994) 457-63 | Tuncay et al., 1994 |
| EFFECT OF OXYGEN ON CHONDROCYTES | |
| E.G. Meyer, C.T. Buckley, S.D. Thorpe, and D.J. Kelly, Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression. J Biomech 43 (2010) 2516-23. | Meyer et al., 2010 |
| P. Malladi, Y. Xu, M. Chiou, A.J. Giaccia, and M.T. Longaker, Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Am J Physiol Cell Physiol 290 (2006) C1139-46. | Malladi et al., 2006 |
| M. Hirao, N. Tamai, N. Tsumaki, H. Yoshikawa, and A. Myoui, Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification. J Biol Chem 281 (2006) 31079-92. | Hirao et al., 2006 |
| Y. Xu, P. Malladi, M. Chiou, E. Bekerman, A.J. Giaccia, and M.T. Longaker, In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis. Tissue Eng 13 (2007) 2981-93. | Xu et al., 2007 |