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Top: UFP mice carrying the target construct. Ugt1a1loxP[FRTneoFRT]loxP were bred into transgenic Albumin-Cre mice to generate UGT1a1F/F/Albumin-Cre mice (UAC mice). Middle (left): Comparisons of TSB levels between UFP and UAC mice during the developmental period. Middle (right): The Kaplan-Meier survival curves analyze the survival rates of UFP and UAC mice. Bottom: Excessively high levels of bilirubin penetrate to the brain of the 15-day-old UAC mouse.
