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. 2017 Feb 14;45(8):4915–4928. doi: 10.1093/nar/gkx099

Figure 2.

Figure 2.

Crystallization and structural characterization of MORF179–190. (A) Ribbon plot of the crystallized MORF179–190 tetramer, orthogonal view on the right. Two adjacent molecules (marine blue, orange) form a tight dimer and contact a distant equivalent dimer (cyan, salmon) with their N-termini and vice versa. Disulfide bridges are shown as sticks and colored by atom type. (B) Close-up view and domain architecture of a single MORF domain with β-sheet 1 folded back onto the globular moiety. Major loops L1–L4 (light yellow), β-sheets β1–β7 (marine blue) and α-helices α1-α3 (red) labeled accordingly. Minor loops and turns are shown in gray. (C) Conservation scores including 124 non-redundant MORF-related sequences obtained by CONSURF (37) plotted on the structure of MORF179–190. (D) Electrostatic surface potential as indicated obtained by APBS and plotted on the surface of MORF179–190. Dashed lines in the ribbon plots represent modeled residues G84-D86 of MORF179–190. Rotation symbols indicate the views relative to (A).