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. 2017 Feb 14;45(8):4915–4928. doi: 10.1093/nar/gkx099

Figure 7.

Figure 7.

The MORF domain resembles a subtilisin PA domain and an NFLD fold. (A) Left – human pro-protein convertase subtilisin/kexin type 9 (gray) with its protease associated (PA) domain (green), (PDB ID: 2W2N). Center panel – Close-up view of a superimposition of MORF179–190 (marine blue) and the PA domain (green). Right panel – side-view of the superimposition (center panel) illustrating the configuration of β-sheet 1 of the PA domain. Colors as in center panel. (B) Left – Thermothoga maritima 4-thio-uracil synthetase ThiI (PDB ID: 4KR6) with its THUMP (light pink), NFLD (pink) and PPase (light green) domains bound to a stretch of tRNA (gold). Center panel – close-up view of a superimposition of ThiI NFLD (pink) and MORF179–190 (marine blue). RNA binding protein loops of ThiI and respective loops of MORF179–190 are indicated. For clarity reasons, β-sheets 6 and 7 and L4 of MORF179–190 which do not align to NFLD are not shown. Right panel – side-view of the superimposition (center panel) illustrating the position of RNA binding loops of ThiI and MORF179–190 loops. Dashed lines in the ribbon plots represent modeled residues G84-D86 of MORF179–190. Rotation symbols indicate views relative to Figure 2A.